Search results for "Lactoferrin hydrolysate"

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An antihypertensive lactoferrin hydrolysate inhibits angiotensin I-converting enzyme, modifies expression of hypertension-related genes and enhances …

2015

This study was aimed to explore whether an antihypertensive lactoferrin hydrolysate (LFH) can inhibit angiotensin I-converting enzyme (ACE) activity and modify the expression of genes related to hypertension in human umbilical vein endothelial cells (HUVEC). LFH induced significant inhibition of ACE activity but it did not affect ACE mRNA levels after 24 h of exposure. LFH treatment significantly affected the expression of genes encoding for proteins involved in nitric oxide pathway such as soluble guanylate cyclase 1 α3 subunit (GUCY1A3; 4.42-fold increase) and nitric oxide synthase trafficking (NOSTRIN; 2.45-fold decrease). Furthermore, expression of the PTGS2/COX-2 gene encoding prostagl…

Endothelial cellsMedicine (miscellaneous)PharmacologyLactoferrin hydrolysateTranscriptomic analysisUmbilical veinNitric oxidechemistry.chemical_compoundDownregulation and upregulationTX341-641Nutrition and DieteticsAngiotensin II receptor type 1biologyNutrition. Foods and food supplyLactoferrinGUCY1A3Nitric oxideACE inhibitionNOSTRINMolecular biologyNitric oxide synthasechemistryNitric Oxide Pathwaybiology.proteinFood Science
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Antihypertensive Mechanism of Lactoferrin-Derived Peptides: Angiotensin Receptor Blocking Effect

2013

Texto del artículo, no incluye figuras ni tablas.

Malemedicine.medical_specialtyAngiotensin receptorPeptideLactoferrin-derived peptidesReceptor Angiotensin Type 1Angiotensin Receptor AntagonistsInternal medicineRenin–angiotensin systemmedicineAnimalsHumansAngiotensin receptor blockerRenin−angiotensin systemReceptorAntihypertensive Agentschemistry.chemical_classificationAngiotensin II receptor type 1Antihypertensive mechanismbiologyLactoferrinAngiotensin IIBovine lactoferrin hydrolysateGeneral ChemistryAngiotensin IIMolecular WeightLactoferrinEndocrinologychemistryVasoconstrictionAngiotensin-converting enzyme inhibitorHypertensionbiology.proteinRabbitsPeptidesGeneral Agricultural and Biological SciencesEx vivo
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